Chapter 588: The Magazine's Reply

Remember [New] in one second!     Intracardiac area 1, doctor's office.

When everyone heard Lu Chen's words, they were stunned for a moment, then shook their heads.

"It's impossible, the patient has chest pain symptoms!"

"I have never seen a patient without disease with this kind of ECG graph..."

"Lu Chen, you should at least rule out other diseases before considering physiological conditions, right?"

...

Everyone was talking about it, and they were not very supportive of Lu Chen's "no disease theory".

In medicine, there is a default rule that considers physiological abnormalities of patients after excluding all possible diseases.

For example, for a patient with proteinuria, you may need to rule out kidney disease before considering physiological proteinuria. (Physiological proteinuria can be seen in changes in body position, strenuous exercise, high temperature, etc.)

It is impossible to consider that proteinuria is caused by physiological conditions at the beginning.

Su Rui on the side also looked at Senior Brother Lu Chen with great curiosity.

She has been following Lu Chen for a while, and knows Senior Brother's character. He is definitely not the kind of person who shoots without a purpose.

Lu Chen must have his own reasons for saying this.

She looked at Lu Chen quietly, looking forward to his next words.

After everyone expressed their opinions, Lu Chen cleared his throat and said, "Teachers, have you ever seen a black person's electrocardiogram before?"

As soon as this was said, everyone was a little confused and shook their heads.

Although Kyoto is an international metropolis, foreigners who come to Kyoto First Affiliated Hospital for treatment will go to the International Department and rarely come to them.

African medicine is backward, and it is rare to see black doctors appear at global conferences.

Xiao Shikang was also in the office, and he asked, "Lu Chen, do you mean that different races have different electrocardiograms?"

Lu Chen nodded, "Yes, in fact, this is easy to understand. For example, the recommended drug dosage in many clinical guidelines is different for different races, such as warfarin, rosuvastatin and other drugs..."

Warfarin, an anticoagulant drug, is more likely to cause bleeding complications in yellow races than white people at the same dose.

Xiao Shikang frowned, "It's just medicine, it can't represent the changes in the electrocardiogram. As long as the black man's heart is on the left and its position in the chest remains unchanged, the electrocardiogram should not change."

The principle of surface electrocardiogram is to use an electrocardiogram machine to record the graph of electrical activity changes generated by each cardiac cycle from the body surface.

Everyone nodded in agreement when they heard Xiao Shikang's words.

Lu Chen shook his head. When it comes to electrocardiogram and electrophysiology, that's his strong point!

"Teacher Xiao, you may have overlooked one point, that is, the adaptive changes of the heart."

Xiao Shikang frowned, "Adaptive changes?"

Lu Chen nodded slightly and continued: "Race is one of the main factors causing adaptive changes in the heart during exercise. More than two-thirds of black athletes have repolarization changes in their electrocardiograms."

"Including the elevation of the J point and the upward elevation of the ST segment arch in the precordial leads (V1~V4), as well as the inversion of the T wave. In the absence of other clinical or electrocardiographic features of cardiomyopathy, the above electrocardiograms show normal variations and do not require further screening."

And the black man on Lu Chen's bed is an athlete by profession.

In the cardiology office, everyone found it difficult to digest what Lu Chen said.

"Lu Chen, are you saying that this patient does not need to undergo any other examinations?" Xiao Shikang asked tentatively.

Lu Chen nodded slightly, "No, it should be a normal physiological change."

"Then how do you explain his chest pain?"

Lu Chen thought for a moment and said, "I have carefully asked the patient. When he had chest pain, he was exercising vigorously, so I think the chest pain is most likely caused by exercise."

"This..." Xiao Shikang was stunned and didn't say much.

All the people present were the best of the younger generation in the field of cardiology, and they would not easily believe Lu Chen's words.

One of the residents who had just started working in the department said, "Lu Chen, are there any literature to support what you said?"

Lu Chen nodded without hesitation, "Of course, it was mentioned in the latest issue of the electrocardiogram analysis of international athletes. If you are interested, I can send the literature to the group."

This literature was also found by Lu Chen just now.

With the "Literature Reading" skill card, it is still very simple to find this kind of literature.

"Lu Chen, send it to the group!" the resident said hurriedly.

"Okay." Lu Chen smiled and nodded.

Everyone has a strong interest in this new knowledge.

Especially this kind of theory, which is completely opposite to everyone's normal thinking mode!

A profession like medicine requires constant learning. If you only rely on experience to treat diseases, you will be eliminated sooner or later.

Everyone clicked on the documents that Lu Chen posted in the group.

Not long after, Lu Chen noticed the prompt that popped up on the system panel.

"Congratulations, received a thank you value +1 from Xiao Shikang!"

"Congratulations, received a thank you value +1 from Su Rui!"

"..."

A series of thank you values, it seems that this time it has been successfully installed again.

What makes Lu Chen most happy is that the completion of the system upgrade has also been improved, and it is one step closer to the next upgrade!

...

Find the correct diagnosis, and the next treatment plan, that is to let the black people decide for themselves.

"Dr. Lu, are you saying that my electrocardiogram performance is physiological?" The black man also showed a smile.

In fact, he felt that there was nothing wrong with him, but the doctors at the school hospital were too nervous.

"Well, we rarely treat foreigners." Lu Chen patiently explained, "But we have read the international clinical guidelines and found that about two-thirds of black athletes will have this kind of electrocardiogram performance, so it is a normal physiological phenomenon. , no need to deal with it at the moment.”

"However, if you are worried, we can provide you with further cardiac examinations, such as cardiac ultrasound, cardiac angiography, etc."

The black man quickly shook his head, "Dr. Lu, I trust your judgment. Let's do this. I also have doctor friends in Africa. Let me tell them about the situation here."

"Of course." Lu Chen nodded.

The international guide is just a piece of paper. It would be best if it could be verified in reality.

Subsequently, black people began to contact their doctor friends in Africa.

After a while, the black man came to the doctor's office and found Lu Chen.

"Dr. Lu, you are so amazing!" The black man showed his white teeth. "My friends in Africa said that my situation is indeed common!"

Everyone in the office heard the black man's words and became more convinced of Lu Chen's previous remarks.

I didn't give Lu Chen any thanks just now, but this time I finally gave Lu Chen some thanks.

Lu Chen smiled slightly. This black man has a high emotional intelligence. He knew he would come to the office and praise him.

"In this case, you can be discharged from the hospital."

After all, black people still had to pay for electrocardiograms and blood tests. Su Rui processed a 24-hour admission and admission record and discharged the black people.

…

After dealing with the black patient, the doctor's office in the heart of the first area had a brief moment of tranquility.

Lu Chen was checking the system panel, calculating how long it would take until the next system upgrade.

At this time, the beautiful junior sister Su Rui suddenly approached Lu Chen.

A vague fragrance was refreshing and made Lu Chen's heart skip a beat.

Having been single and solo for so many years, even Lu Chen, a veteran cadre, had a hard time withstanding this test.

"Brother, this black man just gave me an idea." Su Rui said softly.

"Say." Lu Chen concentrated his attention and didn't look sideways.

Su Rui thought for a while and said slowly: "Brother, in the National Natural Science Project you are currently working on, the experimental group is yellow, and AstraZeneca's experimental group is white. Actually, if you think about it, there is not much conflict, right? "

Lu Chen looked at Su Rui in surprise, this little girl is pretty good!

It is actually possible to draw inferences from one instance to other cases. From the black patients, it reminds me of the National Natural Experiment Project.

He will definitely be a good candidate for scientific research in the future!

"What should I say about this..." Lu Chen touched his chin. Su Rui's words were correct, but she ignored a very important point. "In your opinion, where is the most developed medical field in the world?"

"Europe, the United States, and Japan." Su Rui said, "Most of the clinical treatment guidelines are written by experts from European and American countries. Our Chinese medical experts are translating them, making slight changes, and turning them into domestic guidelines."

"Yes, that's right." Lu Chen nodded, "Then, under the same conditions, if I study yellow people and AstraZeneca studies white people, who will have the greater influence in the end?"

Su Rui was stunned, "It should be AstraZeneca. However, this will not affect our research results, after all, the research subjects are different..."

"It does not affect our results. However, in this cutting-edge field of science, compared with AstraZeneca, if our research results are slower than theirs, the number of experiments is smaller than theirs, and our statistical methods are lower-end than theirs, then our Do the research results have any international influence?" Lu Chen said slowly.

Su Rui glanced at Lu Chen, "Will everyone say... that we plagiarized or plagiarized?"

"Yes." Lu Chen nodded slightly, "Not only does it have little influence, it is very likely that others will say that AstraZeneca is cheating!"

Although Lu Chen didn't want to think about it, this was the reality.

China's medicine is indeed lagging behind the international level. Although it is catching up non-stop and is already at the forefront of the world in some fields, overall, there is still a big gap between it and powerful countries such as Europe, the United States, and Japan.

Why is Lu Chen trying so hard to catch up with AstraZeneca?

Because if we slack off and allow AstraZeneca to complete the experiment ahead of schedule, the results of his experiment will not make any splash internationally and will only be used for domestic purposes.

"Brother, when do you think we in China will surpass foreign countries?" Su Rui sighed slightly. Medical students attach great importance to English ability, because most of the top literature comes from Europe and the United States.

Lu Chen was slightly startled when he heard Su Rui's words. More than Europe, America, and Japan?

A seed slowly sprouted in Lu Chen's heart.

Lu Chen murmured in his heart: "Yes, there will be such a day!"

…

Across the ocean.

Harvard Medical School, USA.

As a review editor (peer review expert) of the "" journal, Fan Boyan will be assigned to review one or two papers every once in a while.

As a Chinese, he has been in the United States for many years. Through his own efforts, he successfully became an associate professor at Harvard Medical School.

As a Chinese, this is also extremely rare at Harvard Medical School.

Today, Fan Boyan received another email from the editorial department of "Professor Fan", "Please help Professor Fan review the manuscript."

Fan Boyan was free, so he opened the email.

As a peer reviewer, he has great power to decide the final result of an article.

Each paper generally has three peer reviewers. As long as it can get the favor of two experts, it can basically be accepted by the editor-in-chief.

There are single-blind and double-blind peer review. The magazine chose double-blind, that is, the contributor and the reviewer are unaware of each other's identity.

"Look at the habits of this English writing, it's too authentic. It should be a paper from a European or American university or research institute."

As a Chinese, Fan Boyan is very clear about the English writing habits of contributors from various countries.

Generally, people from other countries, even if their English level is professional, their ideas for writing papers are close to their own thinking.

The first thing Fan Boyan saw when he saw this paper in front of him was that it was too authentic.

It is absolutely impossible to be written by people from other countries.

"Hey, this is still a study of dapagliflozin!" Fan Boyan murmured, "Is this another paper from AstraZeneca?"

Recently, dapagliflozin has been very popular in the field of international cardiovascular drugs!

Fan Boyan has also read several papers about AstraZeneca's research on dapagliflozin.

"I remember that there seems to be a laboratory in China that is studying dapagliflozin, and it has also published several good papers."

For this kind of cutting-edge hot field, Fan Boyan will have some knowledge.

In particular, this time the research team of "dapagliflozin" also comes from China!

This is a big surprise for Fan Boyan.

As a Chinese, although he is in the United States, his heart is in China. He always pays attention to the consultation in the field of cardiovascular drugs in China.

Fan Boyan threw away the distracting thoughts in his mind and continued to read.

"Hey, something's wrong!"

As a professor and doctoral supervisor in the field of cardiovascular medicine, he immediately noticed the abnormality of this paper.

"The statistical method used in this paper is wrong!"

It's not that the statistical method is too bad, on the contrary, it's too good!

For this type of clinical research experiment, such high-end statistical methods are not needed at all.

Just use a slightly lower level of statistical methods to get the same conclusion.

Fan Boyan frowned slightly. He stopped reviewing the paper on "Dapagliflozin" and found the papers previously published by AstraZeneca.

This comparison made Fan Boyan find something unusual.

The papers published by AstraZeneca before had never tried such advanced statistical methods.

How could a "special case" suddenly appear?

"Isn't this paper in my hand published by AstraZeneca?"

Fan Boyan was shocked by this thought in his mind!

If it was not published by AstraZeneca, then wouldn't it be published by that laboratory in China?

"When did China dare to compete with AstraZeneca in this kind of scientific research?" Fan Boyan still couldn't believe it.

In his subconscious, aren't domestic researchers following behind Europe and the United States to do translation work?

If it is really a domestic laboratory... Thinking of this, Fan Boyan had a faint expectation in his heart.

...

...

...

Kyoto University First Affiliated Hospital.

Doctor's office of the first department of cardiology.

"Lu Chen, you have been in Kyoto for about two months, right?" Xiao Shikang said to Lu Chen.

"Yeah, almost." Lu Chen nodded slightly.

Time really flies. One third of the six-month exchange life has passed in the blink of an eye.

"The graduate department of the hospital asks you students who come to exchange to submit a summary." Xiao Shikang said, "The main thing is to talk about what you have done in the past two months and what you have gained or achieved."

"Okay." Although Lu Chen is not interested in such things, he can only execute the hospital's requirements.

Back to the dormitory.

Lu Chen began to prepare the monthly summary.

He heard that the hospital will also give certain rewards to students with outstanding performance.

The specific criteria for judgment are still unknown.

"It's been two months so soon!" Lu Chen murmured in his heart. There is not much time left for them to conduct clinical research experiments!

According to the previous deployment, if he cannot publish a high-scoring SCI paper within two months and cannot prove that he has the strength to compete with AstraZeneca, then he can only lie down!

"Time is running out." At this time, Lu Chen could only look forward to the reply from the magazine.

As for the other people in the research team, Ke Yue's paper has been accepted, which is good news!

As for Gu Xinyue and Wang Zihao, due to their lack of experience, the paper they completed together was returned for revision.

The other party did not reject the paper directly, but returned it for revision, which also means that there is still a chance.

Lu Chen is temporarily free, taking this opportunity, he just helped Gu Xinyue and Wang Zihao to revise their papers.

...

In a blink of an eye, another week has passed.

The paper that Lu Chen helped Gu Xinyue and Wang Zihao to revise was also accepted by the magazine!

For this, Wang Zihao was excited for several days, and even the always cold old Gu showed a long-lost smile on his face.

However, neither Ke Yue's paper nor Gu Xinyue and Wang Zihao's papers were decisive factors.

They scored 2 points and 3 points respectively. Compared with AstraZeneca's paper, they are not up to par and can only make up the numbers.

"Lu Chen, has your journal not replied yet?"

Wang Zihao asked during lunch, when the research team was having a meal together.

Lu Chen shook his head helplessly: "Not yet."

"If there is no reply this month, will our experiment..." Ke Yue whispered, her expression was a little bitter. She also devoted a lot of effort to Lu Chen's National Natural Science Project.

Hearing this, Lu Chen did not respond, and the atmosphere on the scene was a little dull.

Everyone understood that if Lu Chen's paper was not accepted within this month, then this National Natural Science Project could only be declared flat and could not compete with AstraZeneca at all.

"It's okay, everyone be happy." Seeing that everyone was in a bad mood, Lu Chen could only comfort them, "We are still so young, even if we fail this time, there will be many opportunities in the future!"

Having said that, everyone was still a little unwilling. UU看书 www.uukanshu． net

Just when Lu Chen was about to continue to comfort everyone, suddenly, his phone vibrated slightly.

He thought it was a notification sound from WeChat. When he took out his phone and looked at it, a few big words appeared on the notification bar: "You have a new email, please check it!"

Lu Chen was stunned. New email?

Could it be...

At this time, Wang Zihao came over and looked at it. He was surprised and said: "New email!"

Everyone looked up at Lu Chen when they heard this.

Lu Chen swallowed lightly. He had never been so nervous before.

Unlock the phone and click on the message in the notification bar.

The interface jumped to the email app, and then entered the inbox.

Lu Chen's eyes were focused, looking at the sender's message, then he paused slightly, looked up at Ke Yue and others, "It's a reply from the magazine."

Hearing Lu Chen's words, everyone sat up straight, staring at Lu Chen tightly, not daring to breathe.